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Ananya Anmangandla

Mentor: Hening Lin


Pennsylvania State University – B.S. in Chemistry (Cum Laude), August 2013 – May 2017

Awards and Honors

  • Cornell – Covestro Teaching Excellence Award, May 2018
  • Society of Applied Spectroscopy Student Award, May 2017
  • Penn State – Dean’s List, 2013-2017
  • Penn State – Provost Scholarship, 2013-2017
  • Schreyer Honors Scholar, 2014-2017
  • Penn State – Joseph A. Dixon Memorial Scholarship in Chemistry, 2016-2017
  • Penn State – Marion J. Eyster Scholarship in Chemistry, 2015-2016
  • Penn State – Dalton Undergraduate Student Research Scholarship for Women in Sciences, 2014-2016
  • Penn State – 3M Undergraduate Research Fellowship, May 2015 – July 2015
  • Eberly College of Science Undergraduate Research Support Grant, 2014 and 2015

Research Experience:

  • Dr. Philip Bevilacqua Research Group – Penn State (August 2014 – May 2017).
  • Dr. James Mayer Research Group – Yale University (June – August 2016; 12-week REU program: NSF CENTC Undergraduate Summer Research Program)

Current Research Activities:

Lysyl Oxidase (LOX) catalyzes the transformation of lysine to allysine on collagen and elastin, the primary structural proteins in the extracellular matrix. The formation of reactive aldehyde groups leads to covalent cross-linkages between collagen and elastin, essential for connective tissue maturation. Though lysyl oxidase-like (LOXL) enzymes are presumed to have similar functions, several studies have demonstrated intracellular localization of these enzymes as well. LOXLs have been reported to have important intracellular biological functions and their aberrant activity and expression have been linked to a variety of cancers. For example, LOXLs have been shown to both positively and negatively affect TGFb signaling, an established cancer target. However, the molecular mechanism for their functions are poorly understood. The goal of my project is carry out detailed biochemical studies of LOXL enzymes in order to gain better understanding of LOXL biological functions.


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