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Joseph Haegele

Joseph Haegele

Mentor: Yimon Aye


B.S. in Chemistry (Biology minor), Rensselaer Polytechnic Institute, 2010
M.S. in Biomedical Forensic Science, Boston University, 2012


RPI Patroon Scholar Award (2006-2010),
RPI Dean’s List (2006-2010)
George J. Janz Award for Undergraduate Research in Chemistry (RPI, 2009),
Magna Cum Laude (RPI, 2010)
Boston University Provost’s Scholarship (2010-2012)

American Society of Biochemistry & Molecular Biology (ASBMB) 2015 National MeetingBest Thematic Poster Award” in the category “Mechanistic Impacts of Posttranslational Modifications”; Title: “Chemistry-Driven Approaches to Deconstruct Redox-Linked Signal Transduction Networks”, Boston, MA, April 2015

Research Experience:

Albany College of Pharmacy, Volunteer Research Assistant (Summer 2007)
Rensselaer Polytechnic Institute, Undergrad. Research Group Member in the McGown lab (2008-2009)
Boston University, independent literature-based research in support of M.S. degree; Thesis: “A Mechanism Based Approach to Evaluating Adverse Drug Reactions in a Medico-Legal Setting” (Sept. 2011 – May 2012)
Boston University School of Medicine, Research Study Technician (Oct. 2011 – May 2012)

Current Research Activities:

We are interested in developing small-molecule based techniques for selectively targeting either (1) 4-hydroxy-2-nonenal (HNE), an electrophile with implications in human diseases, or (2) H2O2 to any protein of interest (POI) in living cells. This strategy presents a new way to directly interrogate the specific impacts of either (1) or (2) on the POI, as current approaches rely on treatment of the whole cell with such reactive species, inevitably leading to myriad off target effects. Through application of this methodology, my project focuses on biochemical deconvolution of oxidant and electrophile-response pathways.


Havasi, A., Haegele, J. A., Gall, J. M., Blackmon, S., Ichimura, T., Bonegio, R. G., and Panchenko, M. V. (2013) Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration, Am. J. Pathol. 182, 152-162. PubMed

Fang, X., Fu, Y., Long, M. J., Haegele, J. A., Ge, E. J., Parvez, S., and Aye, Y. (2013) Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells, J. Am. Chem. Soc. 135, 14496-14499. PubMed

Lin, H.-Y., Haegele, J. A., Disare, M. T., Lin, Q., and Aye, Y. (2015) A Generalizable Platform for Interrogating Target- and Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling, J. Am. Chem. Soc. 37, 6232–6244. PubMed


M.S. thesis presentation (Boston University), March 30, 2012; “A Mechanism Based Approach to Evaluating Adverse Drug Reactions in a Medico-Legal Setting”

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