Mentor: Hening Lin
Education:
B.S. Chemistry (Cum Laude), Cameron University, Lawton, OK, 2012
Awards:
Cameron University Outstanding Writers 2009 Award Recipient
Stanton Scholarship – May, 2009-2011
Phi Eta Sigma National Honor Society – 2010
ACS Student Leadership Award Recipient – 2011
National Science Foundation Travel Award Recipient – 2011
Who’s Who Among Students in American Colleges & Universities – 2011,2012
Pi Mu Epsilon National Mathematics Honor Society – 2011
Phi Kappa Phi National Honor Society – 2011
Louis Stokes Scholar – 2011
Wichita Falls-Duncan ACS Local Section Outstanding Chemistry Graduate, 2012
Research Experience:
“Effect of wine on Amyloid-β (1-40) aggregation”- NSF Undergraduate Summer Research Fellowship at University of California, Irvine (2010)
“Proteins involved in converting fatty acids to fuel”- NSF Undergraduate Summer Research Fellowship at Pennsylvania State University (2011)
“Preparation of Solar Cells and Synthetic Dyes”- Cameron University Research Grant (2010-2012)
Current Research Activities:
Desulfotomaculum reducens MI-1 is a bacterium shown to have sulfate- and metal-reducing capabilities. While the complete genome of D. reducens is available, the detailed biochemical pathways used for sulfate and metal reduction by the bacterium is still not clear. My research focuses on identifying and characterizing enzymes important for metal reduction to better understand the mechanism used by the bacterium. Analysis of enzymes and substrates involved in such processes will not only improve understanding of the bacterial physiology but also provide better bioremediation techniques for heavy metal contamination.
Publications:
Otwell, A. E., Sherwood, R. W., Zhang, S., Nelson, O. D., Li, Z., Lin, H., Callister, S. J., and Richardson, R. E. (2015) Identification of proteins capable of metal reduction from the proteome of the Gram-positive bacterium Desulfotomaculum reducens MI-1 using an NADH-based activity assay, Environ. Microbiol. 17, 1977-1990. PubMed
Li, Z., Kim, D. D., Nelson, O. D., Otwell, A. E., Richardson, R. E., Callister, S. J., and Lin, H. (2015) Molecular dissection of a putative iron reductase from Desulfotomaculum reducens MI-1, Biochem. Biophys. Res. Commun. 467, 503-508. PubMed
Sadhukhan, S., Liu, X., Ryu, D., Nelson, O. D., Stupinski, J. A., Li, Z., Chen, W., Zhang, S., Weiss, R. S., Locasale, J. W., Auwerx, J., and Lin, H. (2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function, Proc. Natl. Acad. Sci. U. S. A. 113, 4320-4325. PubMed
Presentations:
“Effect of wine on Amyloid-β (1-40) aggregation” – Poster Presentations, Oklahoma Research Day, Cameron University, November, 2010.
“Effect of wine on Amyloid-β (1-40) aggregation” – Poster Presentations; 241st American Chemical Society National Meeting, Division of Biological Chemistry – Spring, 2011
“Proteins involved in converting fatty acids to fuel” – Poster Presentations; Oklahoma Research Day, Cameron University, November, 2011.
“Proteins involved in converting fatty acids to fuel” – Poster Presentations; 243rd American Chemical Society National Meeting, Division of Chemical Education, Spring, 2012
“Identification of Iron Reductases Using Top-down Proteomics and Heterologous Expression” Ornella D. Nelson (presenting), Zhi Li, Anne E Otwell, Robert W. Sherwood, Sheng Zhang, Hening Lin, Stephen J. Callister, Ruth E. Richardson; Poster presentation at U. S. Department of Energy Office of Science 2014 Genomic Science Contractor-Grantee Meeting XII, February 10-12, 2014.
“Regulation of metabolic enzymes by lysine succinylation”, Poster Session, American Chemical Society National Meeting, Denver, CO, March 22-26, 2015
Presentation entitled “The Legacy of Dr. E. Ann Nalley” honoring her undergraduate advisor who was the spring recipient of the “ACS Award for Encouraging Women into Careers in the Chemical Sciences”. American Chemical Society National Meeting, Denver, CO, March 22-26, 2015